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KMID : 1149220110190020073
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Korean Journal of Oriental Medical Prescription
2011 Volume.19 No. 2 p.73 ~ p.82
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Acute toxicity on Samsoeum and fermented Samsoeum in ICR mice
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Lee Ju-Hye
Hwang Youn-Hwan
Lee Ji-Hye
Yim Nam-Hui
Cho Won-Kyung
Ma Jin-Yeul
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Abstract
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Objectives: This study aims to investigate the acute oral toxicity and safety of Samsoeum (Shensuyin) extracts and fermented Samsoeum extracts.
Methods: For that objective, we used ICR mice. ICR mice were administerd orally with dosage of 1250mg/kg, 2500mg/kg and 5000mg/kg of Samsoeum extracts and fermented Samsoeum extracts.
Results: We daily examined number of deaths, clinical signs, body weights and gross findings for 2 weeks. 1. The results of acute oral toxicity using ICR mice showed that LD50 of value over 5000 mg/kg. 2. Samsoeum extracts and fermented Samsoeum extracts not affect on bodyweight gross findings of ICR mice. 3. The results of Serum chemistry analysis and Complete Blood Count(CBC) through the autopsy were showed normal range values.
Conclusions: Samsoeum extracts and fermented Samsoeum extracts did not show any toxic effects in ICR mice. And oral LD50 value was over 5000mg/kg in ICR mice and it is very safe for ICR mice.
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KEYWORD
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Samsoeum(Shensuyin), acute toxicity, safety, LD50
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